Association between prognostic nutritional index and all-cause mortality in critically ill patients with ventilator-associated pneumonia: a retrospective study based on MIMIC-IV database.

ABSTRACT:

Background

Ventilator-associated pneumonia (VAP) remains a significant clinical challenge in the ICU due to its high mortality rate. The Prognostic Nutritional Index (PNI), a composite biomarker based on serum albumin levels and total lymphocyte counts, reflects nutritional and immune status, but its prognostic significance in VAP patients remains unclear. This study evaluated the association between PNI and mortality in critically ill patients with VAP.

Methods

We retrospectively analyzed data from 1,457 patients diagnosed with VAP from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients were grouped according to PNI quartiles and an identified optimal threshold. Cox regression, restricted cubic spline (RCS) analysis, and subgroup analyses were

SUBMITTER: Ji W 

PROVIDER: S-EPMC12399405 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature