Published population pharmacokinetic models of mycophenolate sodium: a systematic review and external evaluation in a Chinese sample of renal transplant recipients.

ABSTRACT:

Background

Immunosuppressive therapy remains the primary method for preventing rejection in renal transplant recipients. While multiple population pharmacokinetic (popPK) models of mycophenolate sodium (MPS) have been developed for this population, their predictive performance across different clinical settings remains unverified. This study systematically evaluated published MPS popPK models through external validation to assess their extrapolation potential.

Methods

Published MPS popPK models for renal transplant recipients were identified through systematic searches of PubMed, Embase and Web of Science. These models were externally evaluated using a cohort of renal transplant patients receiving MPS therapy at the Affiliated Hospital of Qingdao University. Model prediction

SUBMITTER: Gao T 

PROVIDER: S-EPMC12399562 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature