Tumor associated neutrophils promote prostate cancer progression by mediating neutrophil trap secretion through PSMA1- NF-κB-HIF-1α signaling axis.

ABSTRACT: Prostate cancer (PCa) is a common and deadly cancer in men, and despite its low specificity, PSA testing is the main method that is used to predict prognosis. Effective methods for predicting prognosis in clinical practice are lacking. Here, ① in this retrospective analysis of clinical data of PCa patients, we discovered that patients with PCa have elevated neutrophil levels and a greater risk of complications than patients with prostatic hyperplasia. ② We integrated LASSO regression analysis and machine learning analyses to create a prognostic prediction model involving 6 genes, and this model effectively categorized patients into high-risk and low-risk groups, with higher risk scores indicating a poorer prognosis. Furthermore, we used multivariate regression analysis to confirm that the

SUBMITTER: Dai Q 

PROVIDER: S-EPMC12399615 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature