Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.

ABSTRACT:

Background

Congenital heart anomalies (CHAs) are the most prevalent birth defects, significantly impacting pediatric populations and healthcare systems worldwide. This study provides a comprehensive analysis of the global burden of CHAs, focusing on sex-stratified trends across Socio-Demographic Index (SDI) quintiles from 1990 to 2021.

Methods

Utilizing data from the Global Burden of Disease (GBD) study, we assessed sex-disaggregated metrics including prevalence, incidence, mortality, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for CHAs in 21 GBD regions and 204 countries.

Results

CHA prevalence and incidence remained stable, with higher incidence in lower SDI regions. Mortality rates, age-standardized DALY

SUBMITTER: Ye E 

PROVIDER: S-EPMC12399661 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature