EPEC autotransporter adhesin (Eaa): a novel adhesin identified in atypical enteropathogenic <i>Escherichia coli</i>.

ABSTRACT: Enteropathogenic Escherichia coli (EPEC) is a pathogen that causes diarrhea that can be subdivided into typical (tEPEC) and atypical (aEPEC), based on the production of an adhesin termed Bundle-Forming Pilus (BFP) in the former group. aEPEC is one of the main bacterial pathogens isolated from individuals with diarrhea, and some serotypes have been implicated in diarrheal outbreaks in Brazil, such as the O2:H16. A comparative genomic analysis of aEPEC of this serotype led to the identification of a gene encoding a previously uncharacterized autotransporter protein. In the present study, this novel autotransporter protein was characterized and named EPEC Autotransporter Adhesin (Eaa). The Eaa-encoding gene (eaa) is located in a chromosomal prophage region of 17,014 base pairs,

SUBMITTER: Orsi H 

PROVIDER: S-EPMC12399667 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature