The link between systemic inflammation and mental disorders: a study on CLR, depression, and anxiety in a US cohort.

ABSTRACT:

Background

Depression and anxiety are significant global health concerns, with systemic inflammation playing a critical role in their pathophysiology. Recent studies have highlighted the C-reactive protein to lymphocyte ratio (CLR) as a potential biomarker of inflammation that may be associated with these mental health conditions. However, the relationship between CLR and depression and anxiety, especially within a diverse population, remains underexplored.

Methods

This study utilized data from the National Health and Nutrition Examination Survey (NHANES) (2015-2023) to examine the association between CLR and the prevalence of depression and anxiety. A total of 22,308 participants were included for depression analysis, and 16,138 participants were included for anxiety analys

SUBMITTER: Su Y 

PROVIDER: S-EPMC12399671 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature