Dual <i>vs</i>. isolated anti-Ro antibody positivity in rheumatoid arthritis.

ABSTRACT:

Objective

This study aimed to evaluate the clinical and immunological significance of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies in rheumatoid arthritis (RA), particularly the association of dual antibody positivity with disease severity, systemic manifestations, and therapeutic resistance.

Methods

We conducted a cohort study involving 670 RA patients, stratified into four groups according to anti-Ro52 and anti-Ro60 antibody status: Ro52+/Ro60+, Ro52+/Ro60-, Ro52-/Ro60+, and Ro52-/Ro60-. Clinical characteristics, disease activity scores (DAS28-ESR, DAS28-CRP), systemic complications, and treatment responses were compared among groups. Multivariate logistic regression models identified independent predictors of difficult-to-treat RA (D2T-RA).

Results

Patients with d

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12399673 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature