Cluster randomised trial of intermittent preventive treatment for malaria in infants in area of high, seasonal transmission in Ghana.

ABSTRACT:

Objective

To evaluate the effects of intermittent preventive treatment for malaria in infants (IPTi) with sulfadoxine-pyrimethamine in an area of intense, seasonal transmission.

Design

Cluster randomised placebo controlled trial, with 96 clusters allocated randomly to sulfadoxine-pyrimethamine or placebo in blocks of eight.

Interventions

Children received sulfadoxine-pyrimethamine or placebo and one month of iron supplementation when they received DPT-2, DPT-3, or measles vaccinations and at 12 months of age.

Main outcome measures

Incidence of malaria and of anaemia determined through passive case detection.

Results

89% (1103/1242) of children in the placebo group and 88% (1088/1243) in the IPTi group completed follow-up to 24 months of age. The protecti

SUBMITTER: Chandramohan D 

PROVIDER: S-EPMC1239974 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature