Sex hormone profiles in men with migraine: a cross-sectional, matched cohort study.

ABSTRACT:

Objective

Sex hormones play a key role in migraine pathophysiology, yet their impact in men remains unclear. This study investigates sex hormone profiles and their potential relationship with Calcitonin Gene-Related Peptide (CGRP) in men with episodic migraine.

Methods

We analyzed serum blood levels of sex hormones testosterone, estradiol (E2), progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and CGRP in age and body mass index (BMI)-matched men with and without migraine.

Results

A total of 120 male participants (n = 60 with migraine and n = 60 without migraine) completed the study. The mean age was 44.4 ± 14.4 years in migraine group and 44.5 ± 16.2 in the control group. Men with migraine had lower progesterone levels (0.2 nmoL

SUBMITTER: Triller P 

PROVIDER: S-EPMC12399798 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature