SARS-CoV-2 Vaccine-Elicited Antibody Responses in Human Milk.

ABSTRACT:

Background

SARS-CoV-2 mRNA-LNP immunizations significantly reduce severe coronavirus disease 2019 (COVID-19) disease and have been widely administered throughout the world including those who are pregnant and postpartum. However, our understanding of the immune response within the context of pregnancy and breastfeeding, especially the antibody kinetics and function within the breast milk compartment, is limited. To address this gap, we studied longitudinal blood and breast milk samples from lactating women throughout the primary immunization schedule and for several months after. The overarching goal of this study is to delineate the antibody kinetics, binding breadth, and neutralization capacity of SARS-CoV-2 mRNA-LNP vaccine-elicited antibodies within the breast milk compartment

SUBMITTER: Williams CA 

PROVIDER: S-EPMC12399877 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature