Citri Sarcodactylis Fructus Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammation and Inflammasome Activation.

ABSTRACT: Citri Sarcodactylis Fructus (CSF), an ornamental and edible fruit belonging to the genus Citrus in the Rutaceae family, has been shown to exhibit anti-inflammatory, antioxidant, and anti-obesity effects. However, its impact on the progression of acute lung injury (ALI) remains unclear. In this study, CSF significantly alleviated LPS-induced pulmonary edema in ALI mice and improved oxidative stress markers, as evidenced by reduced serum malondialdehyde (MDA) levels and increased serum superoxide dismutase (SOD) levels. It also decreased macrophage and neutrophil counts as well as protein levels in bronchoalveolar lavage fluid (BALF), and inhibited inflammatory responses-specifically, it reduced the protein and gene expression of IL1β, IL6, and TNF-α in lung tissues, downregula

SUBMITTER: Luo Z 

PROVIDER: S-EPMC12400161 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature