Risk Factors for Microscopic Colitis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Microscopic colitis (MC) is still an underdiagnosed disease due to its primarily histological appearance. We aimed to address the scarcity and inconsistency of data on MC risk factors.

Methods

Our protocol was prospectively registered in PROSPERO (CRD42022286624). We systematically searched PubMed, Embase, and Cochrane from inception to January 6, 2025. Cohort, case-control, and cross-sectional studies were included. Controls were distinguished with or without a histopathological examination. We used the random-effect model to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs).

Results

The systematic search yielded 6493 articles, of which 45 were meta-analyzed. We found increased odds for MC in the case of nonsteroidal anti-inflammatory

SUBMITTER: Rancz A 

PROVIDER: S-EPMC12400255 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature