Photoresponsive Cu-covalent organic polymer as multifunctional artificial enzyme for synergistic infected wound therapy.

ABSTRACT: The escalating challenges associated with antibiotic resistance have posed formidable obstacles in the fight against microbial infections and the prevention of biofilm formation. To address this challenge, we developed PEB-COP-Cu, a low-cost, readily available copper-integrated covalent organic polymer (COP) with dual enzyme-like activities and intrinsic photoresponsiveness, to accelerate infected wound healing. This material was synthesized through the post-metallization process of a COF xerogel (PEB-COP), obtained via a Michael addition elimination reaction, utilizing photoactive tetra-(4-aminophenyl)porphyrin (TAPP) and β-ketoenamine, specifically 1,3,5-tris(3-dimethylamino-1-oxoprop-2-en-yl)benzene (abbreviated as TDOEB), as the fundamental building blocks. PEB-COP-Cu enables mu

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12400305 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature