Cyclodextrin-assisted photostabilization of 5-fluorouracil: a combined kinetic and computational investigation.

ABSTRACT: The photostabilization of 5-fluorouracil (5-FU) has been carried out in the pH range of 2.0-12.0 using cyclodextrins (α-, β-, γ-) as a complexing agent. The inclusion complex formation between 5-FU and CDs has been evaluated using conductometry, FTIR spectroscopy, NMR spectroscopy, differential scanning calorimetry (DSC), and molecular docking simulations. The loss of absorbance at 266 nm for 5-FU in the presence of CDs indicates its photodegradation. The entrapment of 5-FU in α-, β-, and γ-CDs ranges from 22.0-58.0, 30.0-64.0, and 42.0-77.0%, respectively, indicating the formation of inclusion complexes of CDs with 5-FU. The values of Stern-Volmer fluorescence quenching constants and binding constants for α-, β- and γ-CDs are 1.10, 1.69, 3.06 × 10³ L mol^-1 and 2.89,

SUBMITTER: Khurshid A 

PROVIDER: S-EPMC12400308 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature