Effect of SGLT-2 inhibitors on COPD exacerbations in individuals with type 2 diabetes: A meta-analysis and Bayesian sensitivity analysis.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) and Type 2 diabetes mellitus (T2DM) frequently coexist, amplifying morbidity, mortality, and healthcare costs. COPD exacerbations are more frequent and severe in T2DM patients, necessitating therapies addressing both conditions. This systematic review and meta-analysis evaluates the impact of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on COPD exacerbations in T2DM patients.

Methods

Following PRISMA guidelines, we searched PubMed, Embase, and Web of Science until March 2025 for studies assessing SGLT-2i effects on COPD exacerbations in T2DM. Eligible studies included adults with T2DM-COPD overlap, reporting exacerbation outcomes. A random-effects meta-analysis and Bayesian hierarchical models were employed, with

SUBMITTER: Shabil M 

PROVIDER: S-EPMC12400361 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature