Investigating Liposome Membrane Properties: Insights from Langmuir Monolayer Studies in the Corona Protein Environment.

ABSTRACT: Most nanoparticles approved for medical applications are liposome formulations. In the environment of biological fluids, the corona protein was found to alter both the surface of the liposome and its size and zeta potential. As a result, it can also affect the stability of the carrier and its ability to hold a drug and release it sustainably into the cell. The key element of novelty of this research is the introduction of the Langmuir-Blodgett technique together with imaging microscopy to study the interactions between the monolayer corresponding to one liposome leaflet and the corona protein. We applied this approach to study the properties of individual lipid monolayers, which constitute the bilayers of PEGylated or non-PEGylated liposomes exposed to human serum albumin solutions. The th

SUBMITTER: Zaborowska-Mazurkiewicz M 

PROVIDER: S-EPMC12400416 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature