New Approach to Assembling Nucleic Acid Dendrons on a Solid Phase.

ABSTRACT: We report the methodology to synthesize nucleic acid dendrons on a solid support via Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC). Current methods require excess coupling reagents and result in low yields. Our alternative strategy is based on standard solid-phase synthesis followed by 5'-end coupling of a multifunction linker to efficiently afford dendrons. This approach enables the synthesis of DNA/RNA dendrons whose properties are compatible with therapeutic applications.

SUBMITTER: Chik GJ 

PROVIDER: S-EPMC12400419 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature