SMC2 as a potential prognostic biomarker in lung adenocarcinoma and its correlation with immune microenvironment.

ABSTRACT: Structural maintenance of chromosome 2 (SMC2) has been recognized to play an important role in a variety of cancers, but its function in lung adenocarcinoma (LUAD) remains poorly understood. Our research utilized various databases and analytical tools such as The Cancer Genome Atlas, TIMER 2.0, TISIDB, cBioportal, Gene Ontology, Gene Set Enrichment Analysis (GSEA) and Kyoto Encyclopedia of Genes and Genomes, for analyzing SMC2 expression, prognosis significance, immune features and gene alterations in LUAD. In addition, quantitative polymerase chain reaction and immunohistochemistry were used to detect SMC2 expression in LUAD. The clinical data of 70 patients with LUAD in Hunan Provincial People's Hospital were analyzed. SMC2 was markedly upregulated in LUAD cell lines and tissues and was

SUBMITTER: Zheng F 

PROVIDER: S-EPMC12400493 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature