Cardiac light chain amyloidosis secondary to Waldenstrom's macroglobulinemia: A case report and review.

ABSTRACT: Cardiac light chain amyloidosis (AL) secondary to Waldenström's macroglobulinemia (WM) presents a complex challenge in medical practice due to its rarity and diagnostic difficulty. A 67-year-old male presented with symptoms of heart failure and was diagnosed with cardiac AL amyloidosis secondary to WM. The diagnosis of WM was confirmed through a combination of immunoglobulin (Ig) profile with abnormal IgM levels, bone marrow morphology, immunofixation electrophoresis, serum protein electrophoresis and gene mutation analysis. Cardiac amyloidosis was identified through cardiac echocardiography and confirmed through positive Congo red staining of bone marrow and apple green color transformation of an abdominal fat biopsy. The amyloid protein mass spectrometry indicated that the type of cardia

SUBMITTER: Du F 

PROVIDER: S-EPMC12400498 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature