Time series analysis between platelet counts and 60-day mortality in sepsis patients with thrombocytopenia: a retrospective cohort study.

ABSTRACT:

Background

Thrombocytopenia is a prevalent complication and an adverse prognostic factor in sepsis; however, there is a paucity of studies examining the dynamic changes in platelet counts and their association with the prognosis of sepsis patients with related thrombocytopenia. This study aims to retrospectively to investigate the relationship between the dynamic trajectories of platelet counts and early adverse prognostic outcomes in such patients.

Methods

A retrospective observational study was conducted using data from 946 sepsis patients with thrombocytopenia extracted from the Medical Information Mart for Intensive Care (MIMIC-IV) database. A joint latent class model (JLCM) was employed to analyze platelet trajectories over time as part of a time series analysis (TSA).

SUBMITTER: Si Y 

PROVIDER: S-EPMC12400590 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature