Selenomethionine alleviates OTA-induced kidney injury in broilers by modulating ferroptosis.

ABSTRACT: Mycotoxin contamination in food and feed poses a significant threat to human and animal health worldwide. OTA is a common mycotoxin. About 20-30% of global feed is contaminated with OTA, and the annual potential contamination amount exceeds 200 million tons, which has become a major problem of local feed safety. OTA shows strong nephrotoxicity and causes kidney damage in animals and humans. Growing evidence suggests that OTA-induced renal damage is closely associated with ferroptosis. Selenomethionine (SeMet), as the main chemical form of daily dietary selenium supplementation, has pharmacological properties such as anti-oxidation, anti-inflammatory, anti-mutagenic, anti-cancer, anti-viral and anti-bacterial, which can effectively inhibit the nephrotoxicity of OTA. This study aims to estab

SUBMITTER: Tian W 

PROVIDER: S-EPMC12400679 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature