Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis.

ABSTRACT:

Introduction

Cadmium, a major environmental contaminant, induces progressive intestinal damage through bioaccumulation in vivo. Elucidating its pathogenic mechanisms is crucial for developing therapeutic interventions.

Methods

This study employed multi-omics approaches to systematically investigated cadmium-induced ileal dysfunction in Hu sheep and the intervention mechanisms of sodium octanoate.

Results

Phenotypic assessment revealed cadmium exposure caused intestinal barrier impairment and histopathological changes. Integrated transcriptomic-proteomic analysis revealed cadmium disrupted mitochondrial dysfunction via oxidative phosphorylation pathway inhibition. Leading to reactive oxygen species (ROS) overaccumulation. This ROS surge activated ferroptosis, wh

SUBMITTER: Ma Z 

PROVIDER: S-EPMC12400682 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature