The impact of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) on the development of prediabetes in middle-aged and older Chinese adults: a national cohort study.

ABSTRACT:

Background

Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) has demonstrated significant clinical application potential in the evaluation of vascular-related diseases. Our objective was to explore the impact of NHHR on the progression from prediabetes to diabetes or the regression to normal fasting glucose (NFG).

Method

This study utilized data from the first and third waves of the China Health and Retirement Longitudinal Study, involving 2922 participants. Based on the changes in glycemic status during the follow-up period, the outcome variables were categorized into three categories: progression to diabetes, persistence in prediabetes status, or return to NFG. Multivariable logistic regression analyses, restricted cubic spline r

SUBMITTER: Chen J 

PROVIDER: S-EPMC12400698 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature