Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1.

ABSTRACT:

Background

Osteoarthritis (OA), a chronic degenerative disease, is characterized by the loss of articular cartilage, impacting more than 500 million individuals worldwide. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA derived from Salvia miltiorrhiza and has anti-inflammatory and anti-oxidative functions. Although STS shows significant pharmacological effects and mechanisms in treating various diseases in vivo and in vitro, its specific treatments and mechanisms for OA remain largely unknown.

Materials and methods

Primary chondrocytes were stimulated with interleukin-1β (IL-1β) to establish an in vitro OA model. The optimal concentration of STS for application on chondrocytes was determined to be 100 μM using MTT assays. The effects of

SUBMITTER: Xu M 

PROVIDER: S-EPMC12400743 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature