Patient-reported symptom burden and health-related quality of life in patients with aggressive Non-Hodgkin lymphoma: a cross-sectional study.

ABSTRACT:

Background

Patient-reported health-related quality of life (HRQoL) impacted by symptom burden is predictive of overall survival in patients with aggressive Non-Hodgkin lymphoma (NHL).

Method

This cross-sectional study investigated the Core Symptoms Burden Set (CSBS) significantly affecting the HRQoL in patient with aggressive NHL and identify a single cutoff point to separate clinical difference. The MDASI-TCM and EQ-5D-5 L were used to assess the symptom (severity and interference) and HRQoL. The t test, chi-square test or Wilcoxon rank-sum test were used to determine differences in symptoms burden between during and after cancer therapies. A multivariate linear regression model was used to identify associations between the CSBS and HRQoL. Receiver operating characteristic

SUBMITTER: Jin J 

PROVIDER: S-EPMC12400746 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature