Piezo1 is an essential player in volume regulation of human glioblastoma cells.

ABSTRACT: Cell volume regulation is a complex homeostatic process employed by nearly all cell types to adapt to osmotic perturbations and to support physiological processes such as proliferation and migration. This process is critically dependent on the activity of ion channels and transporters, which modulate intracellular water content through the controlled movement of osmolytes across the plasma membrane. We recently demonstrated in a human glioblastoma (GBM) cell line (U87-MG) that hypotonic-induced Ca²⁺ influx through mechanosensitive channels is crucial for activating both large- (BK) and intermediate- (IK) conductance Ca²⁺-activated K⁺ (K_Ca) channels, which in turn drive the regulatory volume decrease (RVD) response. Although growing evidence implicates Piezo

SUBMITTER: Leonardi MV 

PROVIDER: S-EPMC12400783 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature