5-HT₇ antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity.

ABSTRACT: Dysregulated serotonin/5-hydroxytryptamine (5-HT) metabolism and dense mucosal neurite distribution are associated with visceral hypersensitivity (VH), which plays a key role in irritable bowel syndrome (IBS) pain symptoms. The 5-HT receptor subtype 7 (5-HT₇) is involved in neuroplasticity. We aim to investigate the analgesic effects of 5-HT₇ antagonists in mouse models and explore downstream changes of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the enteric neurons. Selective 5-HT₇ antagonists [CYY1005 (CYY), JNJ-18038683 (JNJ) or SB269970 (SB7)] were orogavaged to an IBS-like mouse model of postinflammatory VH after resolution from trinitrobenzene sulfonic acid-induced colitis. Visceromotor response, mucosal neurite outgrowth

SUBMITTER: Lee TY 

PROVIDER: S-EPMC12400787 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature