Characterization of NTS-to-VTA projection neurons reveals higher-order synaptic organization and distinct responsiveness to cholecystokinin.

ABSTRACT: The midbrain ventral tegmental area (VTA) shapes goal-oriented behaviours, including food intake, via dense dopaminergic projections to many key forebrain areas. In addition, the VTA serves as an integrator of neural inputs from throughout the brain that modulate VTA output to produce broad, state-dependent, changes that reflect the balance of internal and external considerations. The brainstem nucleus of the solitary tract (NTS) is the primary site for integration of viscerosensory and taste information conveyed through the cranial nerves and is essential for the control of food intake. Importantly, the NTS has been shown to form direct connections with the VTA, but little is known about the anatomical and neurophysiological nature of these projecting neurons. Using VTA-targeted retrobead

SUBMITTER: Ritchey CR 

PROVIDER: S-EPMC12400789 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature