Cardiovascular outcome in 12-month-old male and female offspring of metformin-treated obese mice.

ABSTRACT: Metformin is increasingly used to treat diabetes in pregnancy, but the effects on adult offspring health remain under-explored. The present study investigated the long-term cardiovascular effects in male and female offspring of maternal metformin treatment using a well-established mouse model of obese glucose intolerant pregnancy. Female mice were given chow, or an obesogenic diet with/without 300 mg kg^-1 day^-1 oral metformin during gestation. At 3, 6 and 12 months of age, male and female offspring were studied longitudinally with tail-cuff plethysmography and echocardiography. At 12 months, tissues were collected for wire myography, histology and molecular analyses. Female offspring of obese dams had elevated blood pressure throughout life, cardiac diastolic dysfunct

SUBMITTER: Schoonejans JM 

PROVIDER: S-EPMC12400794 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature