Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.

ABSTRACT: Neuroimaging studies have identified brain structural and functional alterations in HIV-infected patients; however, the results are inconsistent. This study aimed to characterize the effects of HIV infection on regional gray matter volume (GMV) and resting-state brain activity, and to further investigate the relations between abnormalities in these two modalities. We conducted voxel-wise meta-analysis of voxel-based morphometry (VBM) and functional studies, respectively, to identify regional GMV and brain activity alterations in HIV-infected patients. Multimodal analysis was performed to examine the overlap of regional GMV and brain activity alterations. Meta-regression analysis was conducted to evaluate the potential effects of clinical variables. Eleven whole-brain VBM studies and eight

SUBMITTER: Li Z 

PROVIDER: S-EPMC12400857 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature