The Composite Health Risk Assessment Model (CHARM) Predicts Overall Mortality and Relapse, But Not Non-Relapse Mortality, in Adults Following Unrelated Single-Unit Cord Blood Transplantation

ABSTRACT:

Objective

Concerns about excessive non-relapse mortality (NRM) are a major issue following allogeneic hematopoietic cell transplantation (HCT). Although the HCT-Specific Comorbidity Index (HCT-CI) was established as a stratification model for NRM following allogeneic HCT, the Composite Health Risk Assessment Model (CHARM) score was also developed to predict the risk of NRM and overall mortality following allogeneic HCT from adult donors, particularly in older patients. The CHARM score has been shown to predict these outcomes better than the HCT-CI alone. However, the prognostic value of the CHARM score has not been validated in adult patients undergoing unrelated single-unit cord blood transplantation (CBT). This study aimed to address that gap in the research.

Materials and met

SUBMITTER: Kato S 

PROVIDER: S-EPMC12400884 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature