Separation of platelets by size in a microfluidic device based on controlled incremental filtration.

ABSTRACT: The significant biological and functional differences between small and large platelets suggested by recent studies could have profound implications for transfusion medicine. However, investigating the relationship between platelet size and function is challenging because separating platelets by size without affecting their properties is difficult. A standard approach is centrifugation, but it inevitably leads to premature activation and aggregation of separated platelets. This paper describes the development and validation of a microfluidic device based on controlled incremental filtration (CIF) for separating platelets by size without the cell damage and usability limitations associated with centrifugation. Platelet samples derived from whole blood were used to evaluate the dependence of

SUBMITTER: Dinh MTP 

PROVIDER: S-EPMC12400926 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature