Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles.

ABSTRACT: To better decipher the functional impact of alternative splicing, we classified alternative splicing events in 10,818 pairs of human and mouse genes based on conservation at genome and transcript levels. Expression levels of conserved alternative splices in human and mouse expressed sequence tag databases show strong correlation, indicating that alternative splicing is similarly regulated in both species. A total of 43% (8921) of mouse alternative splices could be found in the human genome but not in human transcripts. Five of eleven tested mouse predictions were observed in human tissues, demonstrating that mouse transcripts provide a valuable resource for identifying alternative splicing events in human genes. Combining gene-specific measures of conserved and diverged alternative splicin

SUBMITTER: Kan Z 

PROVIDER: S-EPMC1240112 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature