Influence of metabolic dysfunction-associated steatotic liver disease on antituberculosis drug-induced liver injury.

ABSTRACT: The risk of antituberculosis drug-induced liver injury (AT-DILI) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is not clear. The aim of this study was to investigate incidence and risk factors associated with AT-DILI in MASLD patients. Retrospectively, a total of 120 MASLD patients who received antituberculosis medication from December 2017 to March 2023 were reviewed, including 91 males and 29 females. The participants were categorized into 2 cohorts based on the presence or absence of liver injury. Risk factors for AT-DILI were analyzed using logistic regression analysis. Among the 120 patients with treatment of tuberculosis complicated with MASLD, 28 (23.3%) patients developed AT-DILI. The remaining 92 (76.7%) patients did not develop AT-DILI. In the

SUBMITTER: Shen Y 

PROVIDER: S-EPMC12401279 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature