Causal relationship between vitamin D and adult height: A bidirectional Mendelian randomization study.

ABSTRACT: Vitamin D is critical for skeletal growth, but its causal link to adult height remains uncertain due to limitations in observational studies and randomized controlled trials. This study aimed to explore the bidirectional causal relationship between circulating vitamin D levels and adult height using Mendelian randomization (MR). A bidirectional 2-sample MR analysis was performed with large-scale genome-wide association study data. Vitamin D data were sourced from the Pan-UKB (n = 383,324 European individuals), and height data from FinnGen R12 (n = 364,629 Finnish individuals). Genetic instruments were selected based on genome-wide significance (P < 5 × 10-8) and independence (linkage disequilibrium r² < 0.001). Multiple MR approaches, including inverse variance weighted (IVW), MR-Egger, an

SUBMITTER: Chen L 

PROVIDER: S-EPMC12401308 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature