Exploring causal links between autoimmune liver diseases, chronic hepatitis C, and thyroid disorders: Evidence from NHANES and GWAS studies.

ABSTRACT: Autoimmune liver diseases (AILDs), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), often have complex interactions with thyroid diseases (TDs), such as hypothyroidism, hyperthyroidism, and Hashimoto thyroiditis (HT). These conditions frequently coexist and may share common autoimmune mechanisms, but their exact relationship remains poorly understood. Chronic hepatitis C (CHC), a viral liver disease, also affects thyroid function, but its interaction with TD is still under investigation. This study explores the causal links between AILD, CHC, and TD using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR) analysis. Data were sourced from NHANES (2013-2018) and various gen

SUBMITTER: Nie Q 

PROVIDER: S-EPMC12401383 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature