Fluconazole resistance and <i>CDR1</i> expression in <i>Candida albicans</i> mediated by the hyperactive Tac1-5 transcriptional activator requires Tlo proteins.

ABSTRACT: Candida albicans is an opportunistic fungal pathogen associated with superficial and systemic infections in humans. Azole antifungal resistance in C. albicans is of clinical concern, and both oral and systemic Candida infections can be difficult to treat due to the lack of alternative antifungal drugs. Expression of a hyperactive form of the transcription factor Tac1 is a major contributor to azole resistance in C. albicans isolates resulting in the increased expression of the azole efflux pump Cdr1. In this study, we investigated whether the Mediator tail component Med2, encoded by the expanded (n=14) TLO gene family of C. albicans, was required for Tac1 activity. A homozygous TAC1-5 gain-of-function point mutation was introduced into WT, <

SUBMITTER: Lim WJ 

PROVIDER: S-EPMC12401524 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature