Estimating the association and timing of occurrence between obesity and related comorbidity outcomes in a real-world setting: A cohort study in the United States.

ABSTRACT: To understand the prevalence, incidence and sequence of obesity-related comorbidities (ORCs) among people with obesity compared with those with a normal body mass index (BMI). People with obesity (BMI ≥30 kg/m²) and normal BMI (BMI 18.5 to <25 kg/m²) were matched 1:1 using a large United States claims-linked electronic health record database. The index date was the date of the first qualifying BMI. Prevalence was assessed at baseline (12 months pre-index date); incidence and sequence of new ORCs were assessed during follow-up. Each cohort included 57 978 people. At least 1 ORC was present at baseline in 61.1% and 49.6% of the obesity and normal BMI cohorts, respectively. During follow-up (median 61 months) event rates per 1000 person-years of new ORCs were higher in t

SUBMITTER: Dabbous F 

PROVIDER: S-EPMC12401642 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature