Evaluation of vitamin D status, vitamin D receptor expression, and innate immune mediators in COVID-19.

ABSTRACT:

Background and objectives

The Coronavirus disease 2019 (COVID-19) pandemic underscored the importance of identifying host factors that influence susceptibility to infection. Vitamin D signaling, mediated via its receptor (VDR), along with innate immune mediators such as antimicrobial peptides (e.g., DEFA1-3) and inflammatory chemokines (e.g., CCL20), plays a critical role in antiviral defense. This study aimed to determine how serum vitamin D status and gene expression of VDR, DEFA1-3, and CCL20 associate with COVID-19 risk in a Lebanese cohort.

Methods

This prospective observational study assessed serum vitamin D concentrations and nasopharyngeal gene expression in Lebanese participants tested for SARS-CoV-2 between January and Marc

SUBMITTER: Missilmani F 

PROVIDER: S-EPMC12401688 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature