Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy.

ABSTRACT:

Background/aims

The placenta expresses and releases specific microRNAs (miRNAs) into the maternal circulation that may influence insulin secretion during pregnancy. We hypothesized that specific decidual/placental miRNAs are associated with maternal insulin secretion during pregnancy.

Methods

In the Genetics of Glucose regulation in Gestation and Growth (Gen3G) prospective cohort, we estimated maternal insulin secretion using the Stumvoll first phase index derived from an oral glucose tolerance test at ~26 weeks of gestation. We quantified miRNAs by small RNA sequencing in placenta (N=435) and first trimester plasma (=422) samples. We used the Limma R package to identify miRNAs associated with the Stumvoll index (P<0.05). We adjusted models for Matsuda index, gravidit

SUBMITTER: Taschereau A 

PROVIDER: S-EPMC12401689 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature