GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice.

ABSTRACT:

Introduction

GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice.

Methods

We tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, in steady-state and autoimmune inflammation of the central nervous system (CNS).

Results

The GM-CSF expression patterns varied by cell type and organ, with CD4⁺, CD8⁺, and CD11b⁺ cells being the main producers. GM-CSF expression was transient and seemingly permanently lost in most cells over time. In a mouse model of CNS autoimmunity, effector memo

SUBMITTER: Azizi G 

PROVIDER: S-EPMC12401695 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature