Global, regional, and national burden of NASH related liver cancer in adults aged 45 and above: an analysis from the GBD 2021 and forecast to 2050.

ABSTRACT:

Introduction

Nonalcoholic steatohepatitis (NASH) is a more advanced stage of Nonalcoholic fatty liver disease (NAFLD) and is particularly common among middle-aged and older adults. NASH-related liver cancer (NALC) is a serious consequence of NASH progression and has become one of the significant causes of global cancer mortality. However, there is currently no comprehensive analysis of the disease burden in this population. This study aims to comprehensively analyze the incidence of NALC among individuals aged 45 and above worldwide from 1990 to 2021 and to project the trends through 2050.

Methods

Using the data from the Global Burden of Disease 2021, we analyzed incidence, prevalence, mortality, and disability-adjusted life years (DALYs) among adults ≥ 45 from 1990 to 2021,

SUBMITTER: Shi J 

PROVIDER: S-EPMC12401703 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature