A genomic tale of inbreeding in western Mediterranean human populations.

ABSTRACT: Consanguineous marriages are common in many worldwide human populations, and the biological consequences for offspring can be relevant at the biomedical level. The current genomic revolution displayed through genome-wide studies is challenging the paradigm in the analysis of consanguinity. Here, we analyzed genomic inbreeding patterns in human populations located at the western edge of the Mediterranean region (Iberia and Morocco). Runs of Homozygosity (ROH) (autozygosity fragments) were identified in 139 autochthonous individuals originating from southern Iberia and Morocco via microarray data. All individuals analyzed carried at least one ROH in their genomes. The genomic inbreeding coefficient (F_ROH) and the presence of ROH islands (ROHi) revealed interesting patterns in the

SUBMITTER: Hernandez CL 

PROVIDER: S-EPMC12401773 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature