Cross-Reactive NSAID Hypersensitivity: Clinical Findings From Aspirin Provocation and Alternative Drug Challenge Testing.

ABSTRACT: Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity reactions are commonly reported but often overestimated due to reliance on clinical history alone. Accurate diagnosis and identification of safe alternative medications are essential for appropriate management. This retrospective study aimed to evaluate the clinical manifestations of NSAID hypersensitivity, assess the diagnostic value and safety of aspirin oral provocation testing, and investigate the tolerability of alternative medications, including acetaminophen, meloxicam, and celecoxib. Patients diagnosed with NSAID hypersensitivity through aspirin provocation testing at a single tertiary hospital were included. Demographics, reaction phenotypes, time intervals from index reactions, provocation outcomes, and tolerability to

SUBMITTER: Koh YI 

PROVIDER: S-EPMC12401939 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature