Cognitive outcomes in chronic obstructive pulmonary disease (COPD)/OSA overlap syndrome compared to obstructive sleep apnea (OSA) alone: a systematic review.

ABSTRACT:

Background

Obstructive Sleep Apnoea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are both independently associated with cognitive impairment. COPD/OSA overlap syndrome could potentially result in greater cognitive impairment that is more than additive. This systematic review evaluates attention, memory, executive function and global cognition in OSA alone compared to COPD/OSA overlap syndrome.

Methods

Systematic searches in MEDLINE, EMBASE, PsycINFO, CINAHL, and CENTRAL identified studies assessing cognitive function in adults with OSA and/or COPD/OSA overlap syndrome. Inclusion criteria required validated diagnostic and cognitive assessment tools. Twelve studies, including 7,424 participants, were reviewed: 10 involving OSA alone and 2 involving overlap syndrome.

SUBMITTER: Alharbi AM 

PROVIDER: S-EPMC12402042 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature