Synthesis, characterization, antioxidant and antimicrobial activities, and computational studies of chitosan nanoparticles loaded with vitamin E and clove essential oil.

ABSTRACT: Efficient encapsulation of bioactive compounds in the food-grade delivery systems to improve their stability, efficiency, and bioavailability and to develop functional foods is a novel and interesting field of research in food industry. Here, two unstable and hydrophobic food ingredients including vitamin E (Vit E) and clove essential oil (CEO) were encapsulated in the chitosan nanoparticles (ChNPs) by the emulsion/ ionic gelation technique without using any toxic surfactant. The physicochemical characterization by DLS, FTIR, FE-SEM, and TEM, confirmed the synthesis of high colloidal and monodispersed ChNPs with narrow size distribution of less than 50 nm. MTT assay showed high biocompatibility of ChNPs after CEO loading, with the increased cellular viability of 72.84% for CEO loaded ChNPs

SUBMITTER: Mahmoudi D 

PROVIDER: S-EPMC12402059 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature