Distinct liver sections exhibit sex-specific gene expression patterns in Lewis rats.

ABSTRACT: Sex-specific differences in liver gene expression have previously been reported in humans and rodents. Clinically, female-to-male liver transplants are known to be associated with adverse post-transplantation outcomes. However, the underlying molecular mechanisms remain largely unknown. Sex-specific gene expression differences may be involved in the post-transplantation outcomes. Here, we analyse sex-specific differences in liver gene expression of Lewis rats on a genome-wide scale. In total, 543 genes exhibited a differential gene expression between male (n = 4) and female (n = 4) rats, with the largest difference found for the transcript ENSRNOG00000009273.7 (log₂FC = 10.69, p < 2.2*10^- 308). Genes downregulated (n = 272) in males were enriched for cholesterol homeo

SUBMITTER: Rajcsanyi LS 

PROVIDER: S-EPMC12402114 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature