LBX1, ESR1, and ESR2 genes DNA methylation level in idiopathic scoliosis.

ABSTRACT: Idiopathic scoliosis (IS) is a multifactorial disease with a genetic and environmental background. Recent studies suggest that epigenetic modifications, such as DNA methylation, may contribute to the IS occurrence and course. The aim of this study was to evaluate the association of LBX1, ESR1, and ESR2 gene methylation levels with susceptibility to and severity of IS. The study group (N = 63) consisted of 56 female and 7 male IS patients. The patients were analyzed in two subgroups based on the Cobb angle: ≤ 75° (N = 36) and > 75° (N = 27). The control group (N = 30) consisted of 27 females and 3 males without IS (23 healthy females, 2 spondylolisthesis, 3 scoliosis from prior thoracotomy, and 2 patients with Scheuermann's disease). DNA was isolated from peripheral blood. The methylation o

SUBMITTER: Janusz P 

PROVIDER: S-EPMC12402125 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature