Umbilical cord-derived exosomes alleviate spinal cord injury by regulating microglial polarization through miR-340-5p-mediated modulation of the JAK/STAT3 signaling pathway.

ABSTRACT: Spinal cord injury (SCI) is a condition of the central nervous system, results in impairments in both sensory and motor functions. Presently, there exists a deficiency in efficacious therapies. Nonetheless, employing exosomes, a derivative of human umbilical cord mesenchymal stem cells (hucMSCs), is proven to be a successful approach in treating SCI, yet the exact way they function is still not well understood. Our research involved conducting a laminectomy on mice's thoracic T8-T10 and subsequently striking the revealed spinal cord using an altered Allen's weight descending apparatus (8 g, height 50 mm, 8 g × 50 mm) to create a model for SCI animals. To create a model of BV2 inflammation, BV2 cells underwent a 24-hour treatment with 1 µg/mL LPS. The expression of related genes and protein

SUBMITTER: Pan Z 

PROVIDER: S-EPMC12402204 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature