Serum metabolomics-driven network pharmacology elucidate the anti-rheumatoid arthritis potential of garden cress.

ABSTRACT: Garden cress (Lepidium sativum L.) has been traditionally utilized for the treatment of various diseases and is increasingly consumed as a functional food and alternative medicine in many countries due to its therapeutic potential. Notably, L. sativum is a promising candidate for mitigating rheumatoid arthritis (RA). This study employed a serum pharmacochemistry approach combined with a network pharmacology strategy to identify the active components and elucidate the underlying mechanisms of L. sativum in RA management. An RA rat model was established using Complete Freund's Adjuvant (CFA). Following L. sativum administration, bioactive serum components were identified and quantified as markers of its pharmacological activity. Twenty-six serum metabolites, including 11 prototype compounds

SUBMITTER: Elsayed SA 

PROVIDER: S-EPMC12402230 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature